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ROS generation is controlled under physiological conditions but increases under pathological conditions, with high ROS levels potentially inducing carcinogenesis and oxidative stress-stimulated diseases

Phosphorylated PRAS40 could strongly activate mTOR which is also known as the PRAS40-Akt-mTOR signal pathway (63)

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Circadian Regulation Influences pineal gland function and melatonin secretion, supporting healthy circadian rhythms, sleep quality, and hormonal balanceall critical for optimal aging and metabolic health