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Liu B, Yang Y, Dai J et al (2006) TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease

2 To stack usefully with that pulse, the GHRH side needs to pulse too

Unlike some peptides that require cycling to prevent receptor desensitization, AOD-9604 does not appear to lose efficacy with continuous use based on available data

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The clinical application of peptides is limited by several factors including target selection, design of sequences, structural modification, high proteolytic susceptibility and preclinical study