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This gives it a half-life long enough to support once-weekly dosing, a major practical advantage over earlier amylin-based therapies like pramlintide, which required multiple daily injections

Hormone-sensitive lipase (HSL) in adipocytes is activated to produce the lipolytic effect, which is then enhanced by indirect processes such as secretion of growth hormone, cortisol, and adrenaline [39]

Dit zou te maken kunnen hebben doordat mensen de extra hoeveelheid carnitine slechts beperkt kunnen opnemen, namelijk 5 tot 15 procent

Four weeks later, liraglutide or saline was injected subcutaneously and dissection was performed as above

Circulation 2012