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Relative to rAmy bound to CTR, Cagri is likely to require extra energy to weaken the salt bridge to attain a CT-like state, thus providing a structural rationale for the smaller population of Cagri-bound particles sampling a CT-like conformation

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Methionine is then activated to S-adenosylmethionine (SAM), which is the body's universal methyl donor for DNA, protein, and lipid methylation