Studies have examined NNMT inhibition in preclinical systems involving energy balance, adipocyte biology, and NAD related chemistry
R 2 is H, C 1 -C 6 alkyl, C 1 -C 6 alkyl-OR 6 , C 1 -C 6 alkylC 3 -C 6 cycloalkyl, C 1 -C 6 alkylC 2 -C 7 heterocycloalkyl, C 1 -C 6 alkyl-CO 2 R 6 , optionally substituted C 1 -C 6 alkylC 6 -C 10 aryl, or optionally substituted C 1 -C 6 alkylC 3 -C 9 heteroaryl
The typical dosage varies by individual needs, but starting doses are usually 50 mg daily, with adjustments over time
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Physical complaints Fatigue, muscle weakness Tingling or numbness in hands and feet Muscle cramps Balance problems or shaky walking Mental complaints Forgetfulness or concentration problems Feelings of gloom or depression Anxiety or irritability Confusion Other signals Headache or dizziness Anemia 'Fog' in your head or feeling of alienation Feeling of not being yourself Note that neurological symptoms can occur without any abnormalities being visible in your blood count