Mechanistically, PYC inhibits NF-B activation, leading to decreased transcription of pro-inflammatory mediators such as TNF-, ICAM-1, and vascular cell adhesion molecule-1, thereby modulating cytokine-driven inflammatory responses and endothelial activation ( Network pharmacology and protein-protein interaction analyses have identified IL-6, TNF, IL-1B, prostaglandin endoperoxide synthase 2, and NF-B1 as core molecular targets of PYC, with Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment highlighting the IL-17 and TNF signaling pathways as key anti-inflammatory mechanisms
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This eye cream delivers multiple targeted benefits through tranexamic acid and glutathione synergy
Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNF in monocytes.Ann Rheum Dis
Proceedings of the National Academy of Sciences of the United States of America, 94 (5), 1967