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[PubMed: 1325608] 229

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At the family level (Figure S6A), the network showed high complexity, with Sutterellaceae serving as a central node highly connected to Prevotellaceae and Lachnospiraceae

This paradox may be explained by the increased insulin resistance and the compensatory intra-portal hyperinsulinemia causing increased hepatic GH sensitivity that increases serum IGF-I and blunts pituitary GH secretion via the negative feedback loop

IGF-1 LR3 has been characterised in peer-reviewed research since the early 1990s, with published studies spanning receptor biology, cell culture, skeletal muscle, stem cell science, and biopharmaceutical production