Although GLP-1RAs seem to have a beneficial influence in reversing many maladaptive brain changes relevant to depression, it should be remembered that at the same time, they are also known to mediate some unfavorable processes such as activation of the HPA axis and intensification of anxiety-like behavior in some animal studies
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In addition to its outstanding glucose-lowering effect, DPP-4i have also shown non-metabolic functional activities, including anti-inflammatory effect and cardiovascular protection, particularly with regards to BP regulation
Phase 3 Trial of Tirzepatide for Obesity (SURMOUNT-1). New England Journal of Medicine , 387(3), 205-216
J Neuroendocrinol 24(12):15051516