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The crystal structure of IRAP in complex with 44 reveals that the enzyme undergoes structural reconfiguration that allows the accommodation of bulky side chains of the inhibitor

The CellChatDB.mouse database, which contains secreted signaling, ECM-receptor, and cell-cell contact ligandreceptor (LR) interactions, was used

Glutathione peroxidase 1 (GPX1) is one of the most abundant members of the GPXs family that protects cell from oxidative damage and maintains the balance of intracellular redox systems ( Ebselen [2-phenyl-1,2-benzoisoselenazol-3(2H)-one] is a synthetic organoselenium radical scavenger compound that has GPX-like activity, and it can directly increase GPX1 activity to mimic the effect of GPX1 overproduction

[] In 2010, the US FDA placed palm oil TRF into the GRAS (Generally Regarded as Safe) category, which indicates that it is suitable for human consumption