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For example, investigators found that orexigenic effects of systemically administered ghrelin (also known as the hunger hormone) were abolished in CB 1 receptor knockout mice 40 , and pharmacological blockade of the CB 1 receptor, via rimonabant administration, attenuated ghrelin-induced activation of the mesolimbic dopamine system a key pathway involved in reward processing 41

Newsholme P, Krause M

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Interestingly, mating with males have been well-documented to impose significant physiological costs on hermaphrodites and to result in drastically shortened lifespan, known as male/mating-induced demise (MID) 57,58

Br J Nutr (2023) 129(11):1897907