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Although GLP-1 class medications have been on the market for 2 decades now, rarer serious side effects are now being seen more simply due to recent increases in the number of people on these medications3
In June 2025, the World Health Organization (WHO) warned that semaglutide drugs, such as Ozempic, Wegovy and Rybelsus, may rarely cause NAION
Similar content being viewed by others Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), such as semaglutide, have emerged as a transformative class of therapeutics that promote weight loss, improve glycemic control, and provide systemic benefits across multiple organ systems 1,2,3,4
& Sizar, O
In rodent studies, semaglutide was associated with dose-dependent and treatment-duration-dependent increases in thyroid C-cell tumours, including medullary thyroid carcinoma
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