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Further, NICE and the BNF says that if there are neurological symptoms present, then every other day injections are the recommended treatment, so all the points you make about B12 being stored and sufficient are not really relevant

Patch dosing will be measured differently (typically in milligrams per day released through the skin) and will require entirely new comparison frameworks

10.1016/j.neuron.2013.10.025 Neuron 68 HussainN

The third and most well known of the toxic metabolites of yeast is acetyl aldehyde

It stimulates pituitary release of endogenous GH, which can lead to downstream increases in insulin-like growth factor-1, or IGF-1