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Subsequent western blot experiments revealed that overexpression of miR-221 led to downregulation of phosphorylated MEK and ERK levels in DPCs, while knockout of miR-221 resulted in their upregulation, with no significant changes observed in the total protein amount of MEK and ERK

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Targeting missense mutations in p53 Mutant p53 expression is considered a promising target for antitumor treatment

A.Segura-AguilarJ.FerrariE.MuozP.ParisI.SulzerD.et al (2017)