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Various signaling pathways including ATM, p38 MAPK and JNK, activated by ROS, are involved in MNNG induction of EBV reactivation and are responsible for multiple phosphorylation of p53

To do this, he is looking into methods to increase the ability of the brain to neutralise ROS, such as boosting levels of the ROS scavenger glutathione

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Genetic and metabolic mapping studies have clearly delineated the absolute dependence of the Aldehyde Dehydrogenase (ALDH) and Monoamine Oxidase (MAO) enzymes on specific vitamins and minerals

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