Early investigations in diverse occupational groups, including oil rig workers, telecommunications employees, and nurses, utilized 24-hour urine collections to compare melatonin output between DSW and NSW, often revealing reduced melatonin levels during NS or rotating shift schedules 172,173,174
doi: 10.1076/ceyr.25.6.381.14238
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The potential mechanism for this effect includes the deposition of collagen through the ERK1/2 signaling pathway, re-epithelialization and glandular tissue formation [3]
Wogonin, a plant derived small molecule, exerts potent anti-inflammatory and chondroprotective effects through the activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes