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In Conclusion While they are highly effective at accelerating weight loss, GLP-1 therapies compromise muscle mass and skin integrity, leading to decreased tone, volume loss, and laxity

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( I L ) Silencing of LS GLP-1R neurons attenuated the anorectic and body weightreducing effect of acutely delivered systemic liraglutide during standard chow or high-sucrose diet over varying durations and dosages