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Common side effects include: Injection site reactions pain, redness, or swelling at the injection site Mild diarrhoea or gastrointestinal upset usually transient Skin reactions itching or rash (uncommon) Hypokalaemia rare, occurring when severe megaloblastic anaemia is corrected rapidly Serious adverse effects are extremely rare but may include anaphylaxis in hypersensitive individuals

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Radiation alters the surrounding mesenchymal and immune microenvironment, reducing the supply of factors essential for ISC survival and repair, such as R-spondin, epidermal growth factor (EGF) and fibroblast growth factor (FGF) 36