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It is also evident that many of the antioxidant enzymes are induced by GSH depletion at the transcriptional level which involves the binding of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factor to the antioxidant response element (ARE) in the promoter region of the genes encoding GCL and glutathione S -transferases [16]

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doi: 10.1016/j.radonc.2021.04.015 30 CalderP