doi: 10.1084/JEM.182.6.1785 159 KuboMKambayashiYTakemotoKOkudaJMutoMOginoK
Due to its effects as a competitive inhibitor of numerous 2-oxoglutarate and Fe 2+ -dependent dioxygenases, succinate is referred to as an oncometabolite
Many clients begin with 12 sessions per week for the first month, then taper to maintenance sessions every 24 weeks
Learning in such models typically leads to distribution of synaptic weights around two modes, at the maximal weight and around zero (Song et al., Importantly, weight-dependent heterosynaptic plasticity does not prevent segregation of weights of synapses subject to distinct patterns of input activity, e.g., groups of inputs with different frequency or correlation of presynaptic firing (Chen et al., 2014, Therefore, we conclude that weight-dependent heterosynaptic plasticity represents a strong candidate mechanism for homeostatic regulation of synaptic weights and balancing their changes during ongoing associative synaptic plasticity and learning in inhibitory neurons
Reports of severe adverse events include allergic reactions ranging from mild rashes to anaphylactic shock, kidney dysfunction particularly with high doses or prolonged use, liver toxicity in susceptible individuals, and thyroid dysfunction affecting hormone regulation
