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The eastern Australian childhood nevus study: site differences in density and size of melanocytic nevi in relation to latitude and phenotype

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Upon activation, mast cells rapidly release pruritogenic mediators such as histamine, prostaglandin D 2 (PGD 2 ), tryptase, and -hexosaminidase (Poto et al., 2022), which collectively stimulate C-type sensory nerve fibers and trigger neuroimmune amplification (Siiskonen and Harvima, 2019)

[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Wang X.-C., Gusdon A