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This is especially important for individuals who are pregnant or breastfeeding, who have a history of cancer (given the peptide's angiogenic, blood-vessel-promoting effects), or who take other medications

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The FLS is an important class of cells and chief contributor of the hyperplasia of synovium, which is involved in the pathogenesis and progression of RA by regulating the secretion of inflammatory mediators like TNF-, IL-6, IL-1, chemo-attractant protein-1 (MCP-1), IL-17, monocytes, cyclooxygenase-2 (COX-2), and IL-1-inducible nitric oxide synthase (iNOS)

Breastfeeding and expecting mothers should avoid consuming silymarin