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Extreme weight loss diets are not only unsafe for many people, but they tend to lead to rebound weight gain when you stop

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Other notable effects include cholelithiasis (1.6% vs 0.7% placebo in STEP 1, related to rapid weight loss), a diabetic retinopathy signal in SUSTAIN-6 (HR 1.76, attributed to rapid HbA1c improvement), and a modest increase in resting heart rate of 2-4 bpm

In pancreatic cells, proglucagon is cleaved to produce glucagon, glicentin-related pancreatic polypeptide (GRPP), intervening peptide-1 (IP-1), and the major proglucagon fragment (MPGF), constituting GLP-1, IP-2, and GLP-2

Patients on GLP-1 drugs tend to have EWDR for one to two years after rapid A1c improvement