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The age-related drop in NAD+ levels is caused by rising levels of CD38, a membrane-bound NADase that degrades both NAD+ and its precursor nicotinamide mononucleotide, according to a 2016 study in mice, which exhibit age-related declines in NAD+ levels similar to those seen in humans (7)

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TB-500 is the 17-amino acid LKKTET-containing fragment of thymosin beta-4, responsible for actin cytoskeleton regulation, cell migration, and anti-inflammatory signaling

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