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Moreover, HSP-70 enhances tumorigenicity and metastasis in murine models and promotes the expression of stemness markers (Nanog, Oct3/4, and SOX2) in stiff hydrogels by increasing the activity of the transcription factor signal transducer and activator of transcription 3 (STAT3) [119]

In this regards, it has been proposed to re-adapt our nutrition to the beneficial characteristics of our pre-agricultural diets [32]

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