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Many gastrointestinal processes can be affected by cannabinoids because their receptors are distributed throughout the human gastrointestinal tract (CB2 is generally expressed by immune cells and the peripheral nervous system, while CB1 is more widely expressed in enteric nervous system, epithelial cells, myenteric and submucosal plexuses and adjacent to motoneurons) [33]

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doi: 10.1016/S1567-5769(03)00024-9

Yes gut-focused detox supplements are among the most effective for bloating and digestive discomfort