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While encouraging, early anti-inflammatory response should not be interpreted as tissue healing

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Consistent with this role of Irs2, increased expression of Irs2 in -cells improves insulin secretion in obese mice and protects against STZ-induced -cell destruction (as reviewed in [547])

Survodutide and orforglipron represent additional emerging molecules in this space, with orforglipron being particularly notable as an oral non-peptide GLP-1 agonist