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Volcano plot visualization of GLP-1MK-801 relative to vehicle revealed transcripts associated with glutamatergic signalling, such as Grin2a , Grin2b , Shisa6 and Slc17a7 among the most differentially upregulated genes (Fig

After 48 weeks of treatment, the results were: -2.1% for the placebo group, -8.7% for the 1 mg group, -17.1% for the combined 4 mg group, -22.8% for the combined 8 mg group, and -24.2% for the 12 mg group

The authors show that prolonged exposure of insulin-secreting cells and isolated mouse islets to elevated levels of the fatty acid palmitate leads to decreased Glp1r expression, impaired incretin potentiation of glucose-stimulated insulin secretion and diminished GLP-1 signalling [4]

One GLP-1R KO mouse had outliers in all three metrics, and was thus excluded

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