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Heijboer, A.C., et al., Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice
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However, a significant increase in Bifidobacterium, Dialister , and Alistipes was reported ( Firmicutes (e.g., Ruminococcus and Blautia ), accompanied by an increase in Bacteroides, Lactobacillus , and Prevotella ( In conclusion, GLP-1 contributes to gut homeostasis and inflammation control through its modulatory effects on immunity, epithelial cell proliferation, and microbial composition ( Figure 1 )
Even though we knew for a long time that dysregulated insulin production was one of the causes of diabetes, especially, obviously Type 1 and Type 2 diabetes, we didn't know exactly why there was this dysregulation, so the GLP discovery helped us understand more about how insulin is created in the body
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