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Although this study did not specifically focus on CIPN, it does suggest that melatonin might improve quality of life in cancer patients undergoing chemotherapy

Important considerations Not all nootropics and brain supplements are supported by high-quality evidence

When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage

Common side effects include mild skin irritation, redness, and itching at the application site

However, when bEnd.3 cells were treated with rTGF 1, claudin-5 immunostaining became increasingly cytoplasmic as doses increased, indicating a disruption of tight junctions (Figure 4c)