GSH has the function of master antioxidant in all tissues and is involved in antioxidant defense, detoxication of xenobiotics, intracellular redox homeostasis, cysteine carrier/storage, cell signaling, protein folding and function, gene expression, cell differentiation/proliferation, immune response and antiviral defense, that make it a Samsonian (mighty) little molecule (1, 2)
Understanding these mechanisms could inform new strategies to prevent metastasis and improve patient outcomes (120)
This pathway has been studied in several in vitro models and is under investigation as a potential therapeutic target in several cancers, including breast, ovarian, liver, and prostate 15,16,17,23
2001), resulting in the pseudomolecular ion of the parent compound
In the setting of diabetes, vitamin D administration has been reported to elicit systemic antioxidant and anti-inflammatory effects by increasing the level of reduced glutathione and reducing IL-8, respectively [18]