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In preclinical studies, combined therapies using mitochondrial-targeting molecules and ROS scavengers showed synergistic effects in protecting nerve fibers [51]

The schistosomicidal activities of PZQ and of potassium antimonial tartrate, a drug used in the past for schistosomiasis and a TGR inhibitor, are reduced in immunosuppressed mice 65 , indicating a crucial role of the host immune system in the mechanism of action of schistosomicidal agents in vivo

has received research funding and materials from Pfizer, Calico, Elysium Health and Metro International Biotech and consulting fees from Pfizer, Elysium Health, Cytokinetics and Altimmune, and holds a patent for using NAD + precursors in liver injury

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The nude mice were randomly divided into the following six experimental groups when tumor volumes reached approximately 50 mm 3 : PBS