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[3] For many, this was the game-changer, obesity treatment was no longer framed as a moral struggle of willpower versus cake. It became a science-backed recalibration of the bodys hunger systems

The pivotal programs are public, the STEP trials for semaglutide in weight management ( The New England Journal of Medicine , 2021), SURMOUNT for tirzepatide in weight management (NEJM, 2022), and SURMOUNT-OSA for tirzepatide in obstructive sleep apnea (NEJM, 2024)

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