semaglutide and cardiovascular outcomes in patients with type 2 diabetes Semaglutide cardiovascular outcomes align more

Clinically 23 vs 25.5 seems largely insignificant the vast majority of the clinical benefits are likely already seen for the vast majority of people at 23% weight loss (an unimaginable weight loss just a few years ago)

10.1210/en.2006-0153 126 VassilopoulosA.FritzK

Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance

Medicare generally excludes medications used for obesity treatment, though there may be rare exceptions

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